Differentiated thyroid carcinoma

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Differentiated thyroid carcinoma

ORPHA:146Disease

Also called Papillary or follicular thyroid carcinoma · Well-differentiated thyroid carcinoma

What it is

A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC).

Key facts

Prevalence
1-9 / 100 000 (annual incidence)
Age of onset
Adolescent, Adult, Childhood
Inheritance
Not applicable
Classified as
Disease

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Genes

BRAFDisease-causing somatic mutation(s)
DIRC3Major susceptibility factor
EIF1AXDisease-causing somatic mutation(s)
FOXE1Major susceptibility factor
GAS8-AS1Disease-causing somatic mutation(s)
HRASDisease-causing somatic mutation(s)
KRASDisease-causing somatic mutation(s)
LPAR4Disease-causing somatic mutation(s)
NDUFA13Disease-causing somatic mutation(s)
NKX2-1Major susceptibility factor
NRASDisease-causing somatic mutation(s)
TERTDisease-causing somatic mutation(s)
ALKPart of a fusion gene
CCDC6Part of a fusion gene
ERC1Part of a fusion gene
ETV6Part of a fusion gene
GOLGA5Part of a fusion gene
NCOA4Part of a fusion gene
NTRK1Part of a fusion gene
NTRK3Part of a fusion gene
PAX8Part of a fusion gene
PCM1Part of a fusion gene
PPARGPart of a fusion gene
RETPart of a fusion gene
TFGPart of a fusion gene
TPRPart of a fusion gene
TRIM24Part of a fusion gene
TRIM27Part of a fusion gene
TRIM33Part of a fusion gene

ICD-10 codes

C73filed under a broader ICD-10 category — shared with 5 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 12027MONDO 0015447OMIM 188550OMIM 607464UMLS C1337013

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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