Classic pyoderma gangrenosum

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Classic pyoderma gangrenosum

ORPHA:538863Clinical subtype

Also called Ulcerative pyoderma gangrenosum

What it is

A rare subtype of pyoderma gangrenosum disease characterized by rapidly progressive, single or multiple, painful, aseptic ulcers which present overhanging, violaceous and undermined borders, surrounding induration and erythema, and granulation tissue (occasionally necrotic tissue and/or a purulent exudate) at the base, mainly affecting the legs (but other body surfaces may also be involved), leading to chronic ulcerations and often regressing with cribriform mutilating scars. The disease presents a chronic relapsing course and systemic features (e.g. fever, malaise, arthralgia, myalgia) may be associated.

Key facts

Prevalence
1-9 / 1 000 000 (annual incidence, Italy)
Age of onset
Adolescent, Adult, Childhood, Elderly
Inheritance
Multigenic/multifactorial
Classified as
Clinical subtype

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Gene

PTPN6Disease-causing germline mutation(s)

ICD-10 codes

L88filed under a broader ICD-10 category — shared with 7 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Cross-references

MONDO 0035235UMLS C5680157

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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