Aplasia of lacrimal and salivary glands

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Aplasia of lacrimal and salivary glands

ORPHA:86815Disease

Also called ALSG · Congenital absence of lacrimal puncta and salivary glands

What it is

A rare autosomal dominant disorder characterized by aplasia, atresia or hypoplasia of the lacrimal and salivary glands leading to varying features since infancy such as recurrent eye infections, irritable eyes, epiphora, xerostomia, dental caries, dental erosion and oral inflammation.

Key facts

Inheritance
Autosomal dominant
Classified as
Disease

Gene

FGF10Disease-causing germline mutation(s)

ICD-10 codes

Q10.4ICD-10 uses a narrower term
Q38.4ICD-10 uses a narrower term

Cross-references

MESH C562407MONDO 0008397OMIM 180920UMLS C0158667

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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