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Start free with EleplanAcute lymphoblastic leukemia
ORPHA:513Clinical group
Also called ALL · Acute lymphoblastic leukemia/lymphoma · Acute lymphocytic leukemia · Precursor lymphoid neoplasm
What it is
A group of rare Non-Hodgkin lymphoma characterized by malignant proliferation of lymphoid cells blocked at an early stage of differentiation. It accounts for 75% of all cases of childhood leukemia cases. The peak incidence occurs between 2 and 5 years of age. Patients may present with symptoms, frequently including lymphadenopathy, hepatosplenomegaly, bone pain, fever and signs of hemorrhage or they may remain asymptomatic. Some patients may also present with acute with a life-threatening hemorrhage, infection, or respiratory distress. Although it primarily affects the bone marrow and peripheral blood, the abnormal cells can infiltrate any organ or tissue.
Key facts
- Prevalence
- 1-5 / 10 000 (Europe)
- Age of onset
- All ages
- Classified as
- Clinical group
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Genes reported in subtypes
Orphanet records these genes on 1 more specific entry under this disorder, not on this entry itself:
A well-studied disease is usually split into subtypes, and the gene is curated on whichever one the evidence belongs to. Open a subtype to see which gene goes with it.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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