chlorpheniramine maleate 4 MG Oral Tablet [Chlor-Trimeton]

Drug interactions

Chlorpheniramine has several drug interactions that may lead to increased risks or reduced efficacy of concomitant medications.

• majorphenytoin — may increase phenytoin levels and toxicity
• majorserotonergic drugs — may result in serotonin syndrome
• majorMonoamine Oxidase Inhibitors (MAOIs) — can potentiate the effects of hydrocodone
• majormuscle relaxants — may enhance respiratory depression
• moderatediuretics — may reduce the efficacy of diuretics
• majorCYP3A4 inhibitors — can increase plasma concentration of hydrocodone
• majorCYP3A4 inducers — can decrease plasma concentration of hydrocodone
• majorbenzodiazepines and other CNS depressants — can increase risk of respiratory depression and sedation
• majoralcohol — can result in increased hydrocodone plasma levels and overdose