R65.2

Non-billable

Severe sepsis

R65.2 is the ICD-10-CM code for Severe sepsis. It is a non-billable category code — use a more specific child code such as R65.20 for billing.

Status
Header (non-billable)
Chapter
R00-R99
Parent
R65
Subcodes
2
Edition
FY2026

R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Includes

  • Infection with associated acute organ dysfunction
  • Sepsis with acute organ dysfunction
  • Sepsis with multiple organ dysfunction
  • Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction

Code first

  • underlying infection, such as:
  • infection following a procedure (T81.4-)
  • infections following infusion, transfusion and therapeutic injection (T80.2-)
  • puerperal sepsis (O85)
  • sepsis following complete or unspecified spontaneous abortion (O03.87)
  • sepsis following ectopic and molar pregnancy (O08.82)
  • sepsis following incomplete spontaneous abortion (O03.37)
  • sepsis following (induced) termination of pregnancy (O04.87)
  • sepsis NOS (A41.9)

Use additional code

  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)

Frequently asked questions

What is ICD-10 code R65.2?
R65.2 is the ICD-10-CM code for "Severe sepsis". It falls under R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.
Is R65.2 a billable code?
No — R65.2 is a non-billable header code. Use a more specific child code (such as R65.20) for billing.
What are the subcodes of R65.2?
R65.2 has 2 more specific child codes, including R65.20, R65.21.

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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