R65.1

Non-billable

Systemic inflammatory response syndrome (SIRS) of non-infectious origin

R65.1 is the ICD-10-CM code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin. It is a non-billable category code — use a more specific child code such as R65.10 for billing.

Status
Header (non-billable)
Chapter
R00-R99
Parent
R65
Subcodes
2
Edition
FY2026

R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Excludes1 — not coded here

  • sepsis- code to infection
  • severe sepsis (R65.2)

Code first

  • underlying condition, such as:
  • heatstroke (T67.0-)
  • injury and trauma (S00-T88)

Frequently asked questions

What is ICD-10 code R65.1?
R65.1 is the ICD-10-CM code for "Systemic inflammatory response syndrome (SIRS) of non-infectious origin". It falls under R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.
Is R65.1 a billable code?
No — R65.1 is a non-billable header code. Use a more specific child code (such as R65.10) for billing.
What are the subcodes of R65.1?
R65.1 has 2 more specific child codes, including R65.10, R65.11.
What is excluded from R65.1?
Excludes1 (not coded here): sepsis- code to infection; severe sepsis (R65.2).

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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