E74.4

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E74.4

Billable

Disorders of pyruvate metabolism and gluconeogenesis

E74.4 is the ICD-10-CM code for Disorders of pyruvate metabolism and gluconeogenesis. It is a billable, specific code valid for reimbursement.

Status
Billable
Chapter
E00-E89
Parent
E74
Edition
FY2026

E00-E89 Endocrine, nutritional and metabolic diseases

What this means — in plain language

MedlinePlus · NIH

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat. A metabolic disorder occurs when abnormal…

Read more about Metabolic Disorders at MedlinePlus ↗

Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.

Includes

  • Deficiency of phosphoenolpyruvate carboxykinase
  • Deficiency of pyruvate carboxylase
  • Deficiency of pyruvate dehydrogenase

Excludes1 — not coded here

  • disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
  • Leigh's syndrome (G31.82)

Medications indicated for this condition

FDA labeling

Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.

Conditions mapped to this code

MedlinePlus · NIH

Plain-language health-topic references grounded in MedlinePlus (NIH/NLM).

14 rare diseases filed under this code

Orphanet · INSERM

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. This code is shared — showing 12 of 14.

Orphadata Science: Free access data from Orphanet. © INSERM 1999.

Frequently asked questions

What is ICD-10 code E74.4?
E74.4 is the ICD-10-CM code for "Disorders of pyruvate metabolism and gluconeogenesis". It falls under E00-E89 Endocrine, nutritional and metabolic diseases.
Is E74.4 a billable code?
Yes — E74.4 is a billable, specific ICD-10-CM code valid for reimbursement.
What is excluded from E74.4?
Excludes1 (not coded here): disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-); Leigh's syndrome (G31.82).

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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